Tandem Hock and Friedel-Crafts reactions allowing an expedient synthesis of a cyclolignan-type scaffold
Résumé
The Hock cleavage is an acid-catalyzed oxydative reaction involving allylic or benzylic hydroperoxides. Since it generates an electrophilic oxocarbenium species, it could be used in tandem processes in the presence of nucleophiles. Here, starting from benzyl(prenyl)malonate substrates, the prenyl moiety was first photooxygenated. The resulting hydroperoxide was directly engaged in a Hock cleavage by adding a Lewis acid in presence of an aromatic nucleophile to promote tandem Friedel-Crafts reactions, also involving the
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